Glutamate decarboxylase-immunoreactive neurons in the aging rat hippocampus are more resistant to ischemia than CA1 pyramidal cells.

作者: M. Frotscher , M. Schlander , S. Hoyer

DOI: 10.1016/0304-3940(88)90687-8

关键词:

摘要: Glutamate decarboxylase (GAD)-immunoreactive, supposedly GABAergic inhibitory, neurons in various fields of the rat hippocampus and pyramidal cells area CA1 were quantified 1 week after transient cerebral ischemia by 4-vessel occlusion. Whereas number Toluidine blue-stained semithin sections found reduced 50% when compared with controls there was no loss GAD-immunoreactive vibratome proper fascia dentata. These data suggest that hippocampal are more resistant to than cells.

参考文章(33)
Wilhelm Sommer, Erkrankung des Ammonshorns als aetiologisches Moment der Epilepsie Archiv für Psychiatrie und Nervenkrankheiten. ,vol. 10, pp. 631- 675 ,(1880) , 10.1007/BF02224538
Charles E. Ribak, Carol A. Hunt, Roy A.E. Bakay, Wolfgang H. Oertel, A decrease in the number of GABAergic somata is associated with the preferential loss of GABAergic terminals at epileptic foci. Brain Research. ,vol. 363, pp. 78- 90 ,(1986) , 10.1016/0006-8993(86)90660-8
M. B. J�rgensen, F. F. Johansen, N. H. Diemer, Removal of the entorhinal cortex protects hippocampal CA-1 neurons from ischemic damage. Acta Neuropathologica. ,vol. 73, pp. 189- 194 ,(1987) , 10.1007/BF00693788
Andrew Francis, William Pulsinelli, The response of GABAergic and cholinergic neurons to transient cerebral ischemia Brain Research. ,vol. 243, pp. 271- 278 ,(1982) , 10.1016/0006-8993(82)90250-5
J. K. Deshpande, B. K. Siesjö, T. Wieloch, Calcium Accumulation and Neuronal Damage in the Rat Hippocampus following Cerebral Ischemia Journal of Cerebral Blood Flow and Metabolism. ,vol. 7, pp. 89- 95 ,(1987) , 10.1038/JCBFM.1987.13
R. Simon, J. Swan, T Griffiths, B. Meldrum, Blockade of N-methyl-D-aspartate receptors may protect against ischemic damage in the brain. Science. ,vol. 226, pp. 850- 852 ,(1984) , 10.1126/SCIENCE.6093256