Association of androgenetic alopecia and hypertension

摘要: Androgenetic alopecia is considered to be associated with coronary heart disease but the explanation of this association remains unknown. Hypertension highly prevalent in patients disease. Essential hypertension linked hyperaldosteronism and spironolactone, an antihypertensive drug which a mineralocorticoid receptor antagonist, has been used for long time treatment androgenic alopecia. We recently observed double transgenic mouse model that overexpression targeted skin induced development prospectively studied androgenetic Caucasian men. Two hundred fifty men aged 35-65 years were consecutively recruited by 5 general practitioners (50 per practitioner). Data collected included age, score simplified Norwood's (0-4), blood pressure or history hypertension, smoking, diabetes mellitus hyperlipidemia, familial alopecia, treatment. Chi-square, Fisher exact tests linear regression statistical analysis. was strongly (p < 0.001). Linear confirmed independent age : odds ratio 2.195 (95% CI 1.1-4.3). Familial also 10.870 4.3-27.1). Other variables (diabetes mellitus, treatment) not limited relatively small study sample hypertension. Association warrants additional studies. The use specific antagonists could interest