IMPROVED AORTOCORONARY BYPASS PATENCY BY LOW-DOSE ASPIRIN (100 mg DAILY): Effects on Platelet Aggregation and Thromboxane Formation
作者： R.L. Lorenz , M. Weber , J. Kotzur , K. Theisen , C.V. Schacky
DOI: 10.1016/S0140-6736(84)92446-2
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摘要: Abstract Prevention of aortocoronary bypass occlusion by aspirin (ASA, 1 × 100 mg per day) was studied in a prospective double-blind trial 83 patients. 60 (72%) were randomly allocated to ASA or placebo starting 24 h after operation. 90% grafts the group and 68% patent at four months. At least one anastomosis occluded 62% patients on 27% those aspirin. Ventricular arrhythmias increased surgery more (12/18) than (5/17). Platelet thromboxane formation collagen tested before operation significantly higher whom developed (occlusion: 40±19, no occlusion: 25±13 ng/ml). A dose day effectively blocked platelet thromboxane-supported aggregation safe postoperative phase. No side effects reported throughout trial. The reduced toxicity with full efficacy favours low infrequent dosage
sci-hub.se 参考文章(33)
M. Terry McEnany, Edwin W. Salzman, Eldred D. Mundth, Roman W. DeSanctis, J. Warren Harthorne, Ronald M. Weintraub, Sharon Gates, W. Gerald Austen, The effect of antithrombotic therapy on patency rates of saphenous vein coronary artery bypass grafts The Journal of Thoracic and Cardiovascular Surgery. ,vol. 83, pp. 81- 89 ,(1982) , 10.1016/S0022-5223(19)37328-3
Reinhard Lorenz, Wolfgang Siess, Peter C. Weber, Effects of very low versus standard dose acetyl salicylic acid, dipyridamole and sulfinpyrazone on platelet function and thromboxane formation in man European Journal of Pharmacology. ,vol. 70, pp. 511- 518 ,(1981) , 10.1016/0014-2999(81)90362-9
J.E. Mayer, W.G. Lindsay, W. Castaneda, D.M. Nicoloff, Influence of Aspirin and Dipyridamole on Patency of Coronary Artery Bypass Grafts The Annals of Thoracic Surgery. ,vol. 31, pp. 204- 210 ,(1981) , 10.1016/S0003-4975(10)60927-7
V Fuster, M K Dewanjee, M P Kaye, M Josa, M P Metke, J H Chesebro, Noninvasive radioisotopic technique for detection of platelet deposition in coronary artery bypass grafts in dogs and its reduction with platelet inhibitors. Circulation. ,vol. 60, pp. 1508- 1512 ,(1979) , 10.1161/01.CIR.60.7.1508
Giulio Masotti, L Poggesi, G Galanti, Rosanna Abbate, GG Neri Serneri, None, DIFFERENTIAL INHIBITION OF PROSTACYCLIN PRODUCTION AND PLATELET AGGREGATION BY ASPIRIN The Lancet. ,vol. 314, pp. 1213- 1216 ,(1979) , 10.1016/S0140-6736(79)92334-1
Manuela Livio, Silvia Villa, Giovanni De Gaetano, Aspirin, thromboxane, and prostacyclin in rats: A dilemma resolved? The Lancet. ,vol. 311, pp. 1307- ,(1978) , 10.1016/S0140-6736(78)91286-2
Michael P. Metke, J.T. Lie, Valentin Fuster, Miguel Josa, Michael P. Kaye, Reduction of intimal thickening in canine coronary bypass vein grafts with dipyridamole and aspirin American Journal of Cardiology. ,vol. 43, pp. 1144- 1148 ,(1978) , 10.1016/0002-9149(79)90145-0
S. Moncada, R. Gryglewski, S. Bunting, J. R. Vane, An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation. Nature. ,vol. 263, pp. 663- 665 ,(1976) , 10.1038/263663A0
George A. Pantely, Scott H. Goodnight, Shahbudin H. Rahimtoola, Bradley J. Harlan, Henry DeMots, Lyle Calvin, Josef Rösch, Failure of Antiplatelet and Anticoagulant Therapy to Improve Patency of Grafts after Coronary-Artery Bypass New England Journal of Medicine. ,vol. 301, pp. 962- 966 ,(1979) , 10.1056/NEJM197911013011803
M. Hamberg, J. Svensson, B. Samuelsson, Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 72, pp. 2994- 2998 ,(1975) , 10.1073/PNAS.72.8.2994