The Protein Partners of GTP Cyclohydrolase I in Rat Organs
作者： Jianhai Du , Ru-Jeng Teng , Matt Lawrence , Tongju Guan , Hao Xu
DOI: 10.1371/JOURNAL.PONE.0033991
关键词:
摘要: Objective GTP cyclohydrolase I (GCH1) is the rate-limiting enzyme for tetrahydrobiopterin biosynthesis and has been shown to be a promising therapeutic target in ischemic heart disease, hypertension, atherosclerosis diabetes. The endogenous GCH1-interacting partners have not identified. Here, we determined proteins rat.
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Th. Müller, D. Woitalla, B. Fowler, W. Kuhn, 3-OMD and homocysteine plasma levels in parkinsonian patients. Journal of Neural Transmission. ,vol. 109, pp. 175- 179 ,(2002) , 10.1007/S007020200013
Georg GOLDERER, Ernst R. WERNER, Christine HEUFLER, Wolfgang STROHMAIER, Peter GRÖBNER, Gabriele WERNER-FELMAYER, GTP cyclohydrolase I mRNA: novel splice variants in the slime mould Physarum polycephalum and in human monocytes (THP-1) indicate conservation of mRNA processing. Biochemical Journal. ,vol. 355, pp. 499- 507 ,(2001) , 10.1042/BJ3550499
Zhe Sha, Laurence M. Brill, Rodrigo Cabrera, Oded Kleifeld, Judith S. Scheliga, Michael H. Glickman, Eric C. Chang, Dieter A. Wolf, The eIF3 Interactome Reveals the Translasome, a Supercomplex Linking Protein Synthesis and Degradation Machineries Molecular Cell. ,vol. 36, pp. 141- 152 ,(2009) , 10.1016/J.MOLCEL.2009.09.026
Alan G. Hinnebusch, eIF3: a versatile scaffold for translation initiation complexes. Trends in Biochemical Sciences. ,vol. 31, pp. 553- 562 ,(2006) , 10.1016/J.TIBS.2006.08.005
Sheldon Milstien, Howard Jaffe, Devanand Kowlessur, Tom I. Bonner, Purification and Cloning of the GTP Cyclohydrolase I Feedback Regulatory Protein, GFRP Journal of Biological Chemistry. ,vol. 271, pp. 19743- 19751 ,(1996) , 10.1074/JBC.271.33.19743
An L Moens, David A Kass, Therapeutic Potential of Tetrahydrobiopterin for Treating Vascular and Cardiac Disease Journal of Cardiovascular Pharmacology. ,vol. 50, pp. 238- 246 ,(2007) , 10.1097/FJC.0B013E318123F854
Claudia M. Campbell, Robert R. Edwards, Cheryl Carmona, Magdalena Uhart, Gary Wand, Alene Carteret, Yu Kyeong Kim, James Frost, James N. Campbell, Polymorphisms in the GTP cyclohydrolase gene (GCH1) are associated with ratings of capsaicin pain Pain. ,vol. 141, pp. 114- 118 ,(2009) , 10.1016/J.PAIN.2008.10.023
Jian Xu, Yong Wu, Ping Song, Miao Zhang, Shuangxi Wang, Ming-Hui Zou, Proteasome-Dependent Degradation of Guanosine 5′-Triphosphate Cyclohydrolase I Causes Tetrahydrobiopterin Deficiency in Diabetes Mellitus Circulation. ,vol. 116, pp. 944- 953 ,(2007) , 10.1161/CIRCULATIONAHA.106.684795
Timothy E. Peterson, Livius V. d'Uscio, Sheng Cao, Xiao-Li Wang, Zvonimir S. Katusic, Guanosine Triphosphate Cyclohydrolase I Expression and Enzymatic Activity Are Present in Caveolae of Endothelial Cells Hypertension. ,vol. 53, pp. 189- 195 ,(2009) , 10.1161/HYPERTENSIONAHA.108.115709
K. Imazumi, T. Sasaki, K. Takahashi, Y. Takai, Identification of a Rabphilin-3A-Interacting Protein as GTP Cyclohydrolase I in PC12 Cells Biochemical and Biophysical Research Communications. ,vol. 205, pp. 1409- 1416 ,(1994) , 10.1006/BBRC.1994.2822