Functional characterization of the promoter region of human TNFAIP1 gene.
作者： Mingjun Liu , Zhenhua Sun , Aidong Zhou , Hong Li , Liping Yang
DOI: 10.1007/S11033-009-9588-1
关键词:
摘要: Tumor necrosis factor, alpha-induced protein 1 (TNFAIP1) is an immediate-early response gene of endothelium induced by TNF alpha. However, little really known concerning the TNFAIP1 expression regulation. To better understand how regulated, we functionally characterized promoter region human gene. Deletion mutation analysis, gel electrophoretic mobility shift, and site-directed mutagenesis assays allowed identification one functional Sp1-binding site within core region. Moreover, chromatin immunoprecipitation analysis indicated that Sp1 was associated in vivo with promoter. Further, overexpression enhanced activity. These findings suggest implicated control basal expression. Accordingly, supposed to be involved elevation alpha induction, thus participate inflammation-associated angiogenesis.
springer.com
sci-hub.se 参考文章(19)
F W Wolf, R M Marks, V Sarma, M G Byers, R W Katz, T B Shows, V M Dixit, Characterization of a novel tumor necrosis factor-alpha-induced endothelial primary response gene. Journal of Biological Chemistry. ,vol. 267, pp. 1317- 1326 ,(1992) , 10.1016/S0021-9258(18)48432-3
Xiao-Wei Liu, Proteomics to display tissue repair opposing injury response to LPS-induced liver injury. World Journal of Gastroenterology. ,vol. 10, pp. 2701- 2705 ,(2004) , 10.3748/WJG.V10.I18.2701
Etienne Richer, Carole G. Campion, Basel Dabbas, John H. White, Mathieu F. M. Cellier, Transcription factors Sp1 and C/EBP regulate NRAMP1 gene expression FEBS Journal. ,vol. 275, pp. 5074- 5089 ,(2008) , 10.1111/J.1742-4658.2008.06640.X
Christopher D Link, Andrew Taft, Vadim Kapulkin, Kyle Duke, Stuart Kim, Qing Fei, Douglas E Wood, Barbara G Sahagan, Gene expression analysis in a transgenic Caenorhabditis elegans Alzheimer's disease model. Neurobiology of Aging. ,vol. 24, pp. 397- 413 ,(2003) , 10.1016/S0197-4580(02)00224-5
Catherine B. Bigger, Irena N. Melnikova, Paul D. Gardner, Sp1 and Sp3 Regulate Expression of the Neuronal Nicotinic Acetylcholine Receptor β4 Subunit Gene Journal of Biological Chemistry. ,vol. 272, pp. 25976- 25982 ,(1997) , 10.1074/JBC.272.41.25976
Toshiaki Inoue, Jun Kamiyama, Toshiyuki Sakai, Sp1 and NF-Y Synergistically Mediate the Effect of Vitamin D3 in the p27Kip1 Gene Promoter That Lacks Vitamin D Response Elements Journal of Biological Chemistry. ,vol. 274, pp. 32309- 32317 ,(1999) , 10.1074/JBC.274.45.32309
Masahiro Ryuto, Mayumi Ono, Hiroto Izumi, Shigeo Yoshida, Herbert A. Weich, Kimitoshi Kohno, Michihiko Kuwano, Induction of Vascular Endothelial Growth Factor by Tumor Necrosis Factor α in Human Glioma Cells Journal of Biological Chemistry. ,vol. 271, pp. 28220- 28228 ,(1996) , 10.1074/JBC.271.45.28220
Jianlin Zhou, Xiaoxiao Hu, Xiwen Xiong, Xin Liu, Yunhai Liu, Kaiqun Ren, Tieshan Jiang, Xiang Hu, Jian Zhang, Cloning of two rat PDIP1 related genes and their interactions with proliferating cell nuclear antigen. Journal of Experimental Zoology Part A: Comparative Experimental Biology. ,vol. 303, pp. 227- 240 ,(2005) , 10.1002/JEZ.A.150
Yasuhiro Nakamura, Yasuhiro Kawachi, Xuezhu Xu, Hideko Sakurai, Yoshiyuki Ishii, Takenori Takahashi, Fujio Otsuka, The combination of ubiquitous transcription factors AP-1 and Sp1 directs keratinocyte-specific and differentiation-specific gene expression in vitro. Experimental Dermatology. ,vol. 16, pp. 143- 150 ,(2007) , 10.1111/J.1600-0625.2006.00528.X
Jianlin Zhou, Kaiqun Ren, Xin Liu, Xiwen Xiong, Xiaoxiao Hu, Jian Zhang, A novel PDIP1-related protein, KCTD10, that interacts with proliferating cell nuclear antigen and DNA polymerase δ Biochimica et Biophysica Acta. ,vol. 1729, pp. 200- 203 ,(2005) , 10.1016/J.BBAEXP.2005.05.005