作者: Artemis Gogos , Michael J. Federle
关键词:
摘要: Streptococcus pyogenes, or Group A (GAS), is a human-restricted pathogen most commonly found in the posterior oropharynx of human host. The bacterium responsible for 600 million annual cases pharyngitis globally and has been to asymptomatically colonize pharynxes 4-30% population. As such, many studies have utilized animals as models order decipher bacterial host elements that contribute bacterial-pharyngeal interaction determine differences between acute infection asymptomatic colonization. aim this review first describe both factors are important pharyngeal persistence GAS humans, then detail colonization murine model, finally compare two evaluate strength model human-GAS interaction.