Animal Models to Understand Host–Pathogen Interactions

摘要: Infectious diseases are the outcome of molecular cross-communication between host and its pathogens. During cross talks, host–pathogen proteomics, genomics, immunological responses highly influenced. Host would respond to their pathogen through several mechanisms for clearance It is always necessary identify underlying pathogenicity. In general, talks complex dynamic in nature that exploits most cell functions. Immune initiated by as a response attack. was found be very difficult, exclusive, ethically inappropriate evaluate notorious interactions cause adverse effects on human health at organism level. Hence, need experimental animal models understand emerges. Incorporation model not only allows identification but also lights into phenotypic impacts ancient times, better understanding virulence determinants antimicrobial therapy has been hindered restrictions adequate tools measure severity infections. Laboratory hosts have employed an alternative mammal infection Caenorhabditis elegans, amoeba, Drosophila melanogaster, Danio rerio. These used owing shorter generation flexibility, affordability study forward reverse genetic analysis. Even though humans excellent pathogens, use studies limited due safety, ethical, expense concerns. Among other primates, monkey, baboons, chimpanzees idyllic mimic infectious diseases. But rodents such mice, rats, rabbits, hamsters, guinea pigs widely proposed application primate models. Here, we review available with focus decipher pathogenicity mechanisms.