Investigating Molecular Recognition by Mass Spectrometry: Characterization of Calixarene-Based Self-Assembling Capsule Hosts with Charged Guests
作者： Christoph A. Schalley , Ronald K. Castellano , Marcus S. Brody , Dmitry M. Rudkevich , Gary Siuzdak
DOI: 10.1021/JA990276A
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摘要: Capsules derived from the reversible assembly of calixarene tetraureas have been characterized by electrospray ionization mass spectrometry. Ion labeling was achieved through encapsulation ammonium ions as guest molecules. The gas-phase ion structure parent determined isotope pattern analysis, inclusion labeled guests, and collision experiments. Competition experiments with different revealed a clear dependence process on size shape ions. formation several heterodimeric capsules, covalently bridged capsule, larger dumbbell-like aggregates containing two three charged guests has observed. results parallel previous findings NMR in solution thus support validity MS method for characterization these complexes gas phase.
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