Topical and Transdermal Drug Delivery: Principles and Practice

摘要: Preface ix About the Editors xi Contributors xiii Part One Current Science, Skin Permeation, and Enhancement Approaches 1. Structure, Function, Permeation 3 Heather A.E. Benson 2. Passive 23 Majella E. Lane, Paulo Santos, Adam C. Watkinson, Jonathan Hadgraft 3. Electrical Physical Methods of Penetration 43 Jeffrey Grice, Tarl W. Prow, Mark A.F. Kendall, Michael S. Roberts 4. Clinical Applications Transdermal Iontophoresis 67 Dhaval R. Kalaria, Sachin Dubey, Yogeshvar N. Kalia 5. In Vitro Methodology 85 Barrie Finnin, Kenneth A. Walters, Thomas J. Franz 6. Assessment: Tape Stripping 109 Sandra Wiedersberg Sara Nicoli 7. Microdialysis 131 Rikke Holmgaard, Jesper B. Nielsen, Eva Benfeldt 8. Permeation: Spectroscopic 155 Lane 9. Assessment in Man: Vivo Correlation 167 Paul Lehman, Sam G. Raney, 10. Risk 183 Jon Heylings Two Topical Product Development 11. An Overview from Concept to Approval 203 Watkinson 12. Regulatory Aspects Drug for Dermal Products 217 William K. Sietsema 13. Toxicological Pre-clinical Considerations Novel Excipients New Chemical Entities 233 Andrew Makin Jens Thing Mortensen 14. Formulation 255 Marc Brown, Robert Turner, Sian T. Lim 15. 287 Miller 16. Sensitivity Irritation Testing 309 Belum Viswanath Reddy, Geetanjali Sethi, Howard I. Maibach 17. Delivery: Understanding Market Opportunity 345 Hugh Alsop 18. Delivery Today 357 19. Future Trends: Diseases Treatment 367 Simon Danby, Gordon Duff, Cork Index 409