Long-Term Estrogen Therapy Improves Vascular Function in Male to Female Transsexuals

摘要: Abstract Objectives. This study sought to examine the effects of long-term estrogen therapy on vascular function in male female transsexuals and compare findings with those observed men premenopausal women. Background. Gender differences coronary artery disease have largely been attributed beneficial plasma lipids However, vasculature not widely studied. Methods. We compared 14 transsexuals, age-matched 15 Flow-mediated vasodilation response nitroglycerin were assessed brachial using noninvasive ultrasound. Results. was similar women but greater than that ([mean ± SE] 11.5 1.3% 9.4 1.1% vs. 5.2 1.0% respectively, p Conclusions. Long-term appears improve occurs despite higher triglyceride levels presence small, dense LDL-C. The are gender specific or solely mediated through endothelium-derived nitric oxide. (J Am Coll Cardiol 1997;29:1437–44)