Estrogen replacement and coronary artery disease. Effect on survival in postmenopausal women.

摘要: The relationship among postmenopausal estrogen use, coronary stenosis, and survival was examined retrospectively in 2268 women undergoing angiography. patients were selected for study if their age 55 years or older at the time of angiography they had previously undergone bilateral oophorectomy. Postmenopausal use 1178 with artery disease (greater than 70% stenosis) 644 mild to moderate (5% 69% compared 446 control subjects (0% using life-table analysis. Over 10 follow-up, there no significant difference initially free lesions on arteriography who either never used (377) ever (69) estrogens. Among 10-year those estrogens 85.0% it 95.6% 99 "ever users." Survival 60.0% more stenosis 97.0% 70 users. "never users" group (65 vs 59 years), a lower proportion cigarette smokers (40% 57.1%), higher diabetes (21.7% 12.9%) hyperlipidemia (58% 44%), approximately equal numbers hypertensives (56.0% 54.3%). Cox's proportional hazards model estimate as function multiple covariables. Estrogen found have significant, independent effect women. We conclude that replacement after menopause prolongs when is present, but has less absence disease.