Lipid rafts, the sarcoplasmic reticulum and uterine calcium signalling: an integrated approach.

摘要: The pathways involved in Ca2+ signalling the uterus remain incompletely understood, impairing our ability to prevent preterm and difficult labours. In this review we focus on two elements pathway of that have recently emerged as playing important roles: membrane lipid rafts sarcoplasmic reticulum. We examine evidence for discuss their functional role. suggest increases cytosolic [Ca2+] contractility occur with raft disruption are due, at least part, effects large conductance Ca2+-activated K+ (BK) channels localized rafts. role SR contributing subsarcolemmal microdomains is evaluated, along its interactions ion plasma membrane. Thus, play an important, but uterus, integrating them into other a challenge further research. changes pregnancy, from promoting quiescence via BK or uptake, entry term, relate data clinical outcome obese pregnant women.