Characterization of TET and IDH gene expression in chronic lymphocytic leukemia: comparison with normal B cells and prognostic significance.

作者: Michaël Van Damme , Emerence Crompot , Nathalie Meuleman , Marie Maerevoet , Philippe Mineur

DOI: 10.1186/S13148-016-0298-Y

关键词:

摘要: Background Chronic lymphocytic leukemia (CLL) is the most common hematological malignancy in western countries, characterized by a heterogeneous clinical course. Although genetic studies have identified chromosomal aberrations or specific mutations, epigenetic changes been poorly CLL.

参考文章(62)
Kuo-Wang Tsai, Guan-Cheng Li, Chien-Hsun Chen, Ming-Hsin Yeh, Jer-Shyung Huang, Hui-Hwa Tseng, Ting-Ying Fu, Huei-Han Liou, Hung-Wei Pan, Sheng-Feng Huang, Chien-Chou Chen, Hui-Yu Chang, Luo-Ping Ger, Hong-Tai Chang, Reduction of global 5-hydroxymethylcytosine is a poor prognostic factor in breast cancer patients, especially for an ER/PR-negative subtype. Breast Cancer Research and Treatment. ,vol. 153, pp. 219- 234 ,(2015) , 10.1007/S10549-015-3525-X
Hélène Gary-Gouy, Alexander Sainz-Perez, Jean-Brice Marteau, Anne Marfaing-Koka, Jozo Delic, Hélène Merle-Beral, Pierre Galanaud, Ali Dalloul, Natural phosphorylation of CD5 in chronic lymphocytic leukemia B cells and analysis of CD5-regulated genes in a B cell line suggest a role for CD5 in malignant phenotype. Journal of Immunology. ,vol. 179, pp. 4335- 4344 ,(2007) , 10.4049/JIMMUNOL.179.7.4335
Qiu-Ling Ma, Jing-Han Wang, Yun-Gui Wang, Chao Hu, Qi-Tian Mu, Meng-Xia Yu, Lei Wang, Dong-Mei Wang, Min Yang, Xiu-Feng Yin, Fei-Fei Chen, Sha-Sha Lu, Jian Chen, Zhi-Juan Zhu, Sai-Juan Chen, Jie Jin, High IDH1 expression is associated with a poor prognosis in cytogenetically normal acute myeloid leukemia International Journal of Cancer. ,vol. 137, pp. 1058- 1065 ,(2015) , 10.1002/IJC.29395
Diego F. Coutinho, Bárbara C.R. Monte-Mór, Danielle T. Vianna, Soraia T. Rouxinol, Anna Beatriz W. Batalha, Ana Paula S. Bueno, Alice M. Boulhosa, Teresa S. Fernandez, Maria S. Pombo-de-Oliveira, Luciana M. Gutiyama, Eliana Abdelhay, Ilana R. Zalcberg, TET2 expression level and 5-hydroxymethylcytosine are decreased in refractory cytopenia of childhood. Leukemia Research. ,vol. 39, pp. 1103- 1108 ,(2015) , 10.1016/J.LEUKRES.2015.07.005
T. Hamblin, Chronic lymphocytic leukaemia: one disease or two? Annals of Hematology. ,vol. 81, pp. 299- 303 ,(2002) , 10.1007/S00277-002-0476-1
Carina Frauer, Thomas Hoffmann, Sebastian Bultmann, Valentina Casa, M. Cristina Cardoso, Iris Antes, Heinrich Leonhardt, Recognition of 5-Hydroxymethylcytosine by the Uhrf1 SRA Domain PLoS ONE. ,vol. 6, pp. e21306- ,(2011) , 10.1371/JOURNAL.PONE.0021306
Xose S Puente, Magda Pinyol, Víctor Quesada, Laura Conde, Gonzalo R Ordóñez, Neus Villamor, Georgia Escaramis, Pedro Jares, Sílvia Beà, Marcos González-Díaz, Laia Bassaganyas, Tycho Baumann, Manel Juan, Mónica López-Guerra, Dolors Colomer, José MC Tubío, Cristina López, Alba Navarro, Cristian Tornador, Marta Aymerich, María Rozman, Jesús M Hernández, Diana A Puente, José MP Freije, Gloria Velasco, Ana Gutiérrez-Fernández, Dolors Costa, Anna Carrió, Sara Guijarro, Anna Enjuanes, Lluís Hernández, Jordi Yagüe, Pilar Nicolás, Carlos M Romeo-Casabona, Heinz Himmelbauer, Ester Castillo, Juliane C Dohm, Silvia de Sanjosé, Miguel A Piris, Enrique De Alava, Jesús San Miguel, Romina Royo, Josep L Gelpí, David Torrents, Modesto Orozco, David G Pisano, Alfonso Valencia, Roderic Guigó, Mónica Bayés, Simon Heath, Marta Gut, Peter Klatt, John Marshall, Keiran Raine, Lucy A Stebbings, P Andrew Futreal, Michael R Stratton, Peter J Campbell, Ivo Gut, Armando López-Guillermo, Xavier Estivill, Emili Montserrat, Carlos López-Otín, Elías Campo, None, Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia Nature. ,vol. 475, pp. 101- 105 ,(2011) , 10.1038/NATURE10113