Morphologic alterations in ovine placenta and fetal liver following induced severe placental insufficiency
作者： Cecilia Y. Cheung , Ljubica Bogic , Robert Gagnon , Richard Harding , Robert A. Brace
DOI: 10.1016/J.JSGI.2004.06.010
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摘要: Objectives:Umbilical-placental embolization with microspheres has been used as a model of placental insufficiency and intrauterine growth restriction (IUGR). However, the effects on structure organ morphology resulting IUGR fetus are relatively unexplored. In this study using ovine fetuses, we determined location distribution within placenta explored extent fetal morphologic changes induced by embolization. We hypothesized that administered into umbilical circulation over 4 days would cause damage without significant alterations in kidney or liver.Methods:Eleven pregnant sheep at 118 ± 1 (SE) days' gestation were studied. six was injection 15-μm diameter successive descending aorta proximal to arteries. Five fetuses served time controls.Results:In embolized fetuses...
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