Diffusion of rat atrial natriuretic factor in thermoreversible poloxamer gels.
作者： Julianna Juhasz , Vincent Lenaerts , Philippe Raymond , Huy Ong
DOI: 10.1016/0142-9612(89)90103-8
关键词:
摘要: Concentrated poloxamer 407 solutions display a negative thermorheological behaviour, resulting in higher viscosity at body temperature than below. This could be exploited for various controlled delivery applications including the nasal of peptides. The rheology gel and diffusion ANF were studied as function temperature. A theory is proposed, according to which rise creates an intermicellar network increase. drug appears limited only by presence micelles lengthens pathways not significantly influenced formation this network.
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