Compartmentalization and regulation of insulin signaling to GLUT4 by the cytoskeleton.
作者： Craig A. Eyster , Ann Louise Olson
DOI: 10.1016/S0083-6729(08)00608-0
关键词:
摘要: One of the early events in development Type 2 diabetes appears to be an inhibition insulin-mediated GLUT4 redistribution cell surface tissues that express GLUT4. Understanding this process, and how it begins breakdown insulin resistance is quite important as we face treatment prevention metabolic diseases. Over past few years, increasing number laboratories have produced compelling data demonstrate a role for both actin microtubule networks regulation surface. In review, explore process from insulin-signal transduction fusion membrane vesicles, focusing on studies implicated cytoskeleton. We see body work network cytoskeleton play roles targets action effectors signaling leading changes glucose uptake.
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