Maternal Human Milk Oligosaccharide Profile Modulates the Impact of an Intervention with Iron and Galacto-Oligosaccharides in Kenyan Infants

摘要: There is little data on human milk oligosaccharide (HMO) composition in Sub-Saharan Africa. Iron fortificants adversely affect the infant gut microbiota, while co-provision of prebiotic galacto-oligosaccharides (GOS) mitigates most adverse effects. Whether variations maternal HMO profile can influence response to iron and/or GOS unknown. The aim this study was determine profiles and secretor/non-secretor phenotype lactating Kenyan mothers investigate their effects a fortification intervention with 5 mg (2.5 as sodium ethylenediaminetetraacetate 2.5 ferrous fumarate) 7.5 g GOS. We studied mother-infant pairs (n = 80) participating 4-month trial which infants (aged 6.5-9.5 months) received daily micronutrient powder without iron, or assessed: (1) secretor status composition; (2) microbiota cross-sectional analysis at baseline trial; (3) interactions between groups during inflammation, status, growth infectious morbidity. Secretor prevalence 72% HMOs differed secretors non-secretors over time lactation. did not predict microbiota. secretor-status-by-intervention-group interaction Bifidobacterium (p 0.021), Z-scores for length-for-age 0.022) weight-for-age 0.018), soluble transferrin receptor 0.041). In no group, longitudinal diarrhea higher among (23.8%) than (10.4%) 0.001). conclusion, may modulate fortificant iron; compared mothers, non-secretor be more vulnerable effect but also benefit from