Magnesium sulfate versus Lidocaine pretreatment for prevention of pain on etomidate injection: A randomized, double-blinded placebo controlled trial.

摘要: Objective: Etomidate is an imidazole derivative and formulated in 35% propylene glycol. When given without a rapid lidocaine injection, etomidate associated with pain after injection. Magnesium (Mg) calcium channel blocker influences the N-methyl-D-aspartate receptor ion channel. The aim of study to evaluate efficiency preemptive injection magnesium sulfate on alleviation intravenous Methods: In randomized, double-blinded trial study, 135 adult patients scheduled for elective outpatient or inpatient surgery were divided into three groups. Group M received 620 mg sulfate, L 3 ml 1% S normal saline, all volume 5 mL followed by maximal dose 0.3 mg/kg etomidate. Pain was assessed four-point scale: 0 = no pain, 1 mild 2 moderate severe at time pretreatment Findings: About 60% control group had during as compared 22.2% 40% groups, respectively. There difference induction score between treatment significantly ( P 0.01) observed differences scores saline 0.044). Conclusion: Intravenous are comparably effective reducing etomidate-induced pain.