Dysregulation of Hedgehog, Wnt and Notch signalling pathways in breast cancer.

摘要: There has been a significant decrease in mortality from breast cancer the last two decades. This attributed to introduction of mammographic screening and development specialised therapies, notably anti-estrogens such as tamoxifen estrogen receptor (ER) positive tumours, adjuvant chemotherapy. More recently monoclonal antibodies trastuzumab directed against Her2-overexpressing tumours show promise improving outcome this aggressive subtype. While there have advances, number clinical challenges still remain, particularly targeted therapies for other forms lacking ER or Her2, basal-like carcinomas. Identification new therapeutic targets poor prognosis groups will be critical further improvements treatment. Proper functioning Hedgehog, Notch Wnt signalling pathways is required normal during early life these also play key role regulation maintenance stem cells. Increasing evidence implicates dysregulation progression malignancies, including cancer. review presents current aberrations proposes that may represent novel