Eosinophils, bronchitis and asthma: pathogenesis of cough and airflow obstruction.

摘要: Eosinophilic airway inflammation is commonly observed in chronic cough patients with asthma and non-asthmatic eosinophilic bronchitis. Indeed bronchitis are amongst the commonest causes of accounting for about 25 10% cases respectively. In most trigger that uncertain; however removal potential triggers important to consider particular respect occupational exposure known sensitizers. both conditions improves subjectively objectively following treatment corticosteroids. This improvement associated presence an eosinophilia, but whether cause or epiphenomenon uncertain. The success anti-IL5 reduce exacerbations contrasts lack efficacy modify therefore challenges a causal association. Both can lead onto remodeling result persistent airflow obstruction. However, response corticosteroid therapy generally very good limited long term data available suggests usually have benign course. Interestingly, using CT imaging analysis sub-epithelial matrix deposition does suggest eosinophil may play role remodeling.