Structural insights into 5′ flap DNA unwinding and incision by the human FAN1 dimer
作者： Qi Zhao , Xiaoyu Xue , Simonne Longerich , Patrick Sung , Yong Xiong
DOI: 10.1038/NCOMMS6726
关键词:
摘要: FAN1 is a structure-specific nuclease that plays major role in eliminating highly cytotoxic interstrand DNA crosslinks. Here, Zhao et al. present several crystal structures of complex with substrates and biochemical analyses establish how functions to resolve
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