Biomimetic strategies for the glioblastoma microenvironment

摘要: Glioblastoma multiforme (GBM) is a devastating type of tumor with high mortality, caused by extensive infiltration into adjacent tissue and rapid recurrence. Most therapies for GBM have focused on the cytotoxicity, not targeted spread. However, there been numerous attempts to improve therapy addressing invasion, through understanding mimicking its behavior using three-dimensional (3D) experimental models. Compared two-dimensional models in vivo animal models, 3D can capture invasive motility glioma cells within environment comprising many cellular non-cellular components. Based engineering techniques, invasion has investigated biologically relevant environment, from biophysical biochemical perspectives, clarify pro-invasive factors GBM. This review discusses recent progress techniques modeling microenvironments suggests future directions respect recreating microenvironment preclinical applications.