Parental Origin–Dependent, Male Offspring–Specific Transmission-Ratio Distortion at Loci on the Human X Chromosome
作者： A.K. Naumova , M. Leppert , D.F. Barker , K. Morgan , C. Sapienza
DOI: 10.1086/301860
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摘要: Summary We have analyzed the transmission of maternal alleles at loci spanning length X chromosome in 47 normal, genetic disease–free families. found a significant deviation from expected Mendelian 1:1 ratio grandpaternal:grandmaternal Xp11.4-p21.1. The distortion inheritance was only among male offspring and manifested as strong bias favor grandfather. no evidence for heterogeneity families, which implies that major determinant involved generation non-Mendelian is epigenetic. Our analysis recombinant chromosomes inherited by indicates an 11.6-cM interval on short arm chromosome, bounded DXS538 DXS7, contains imprinted gene affects survival embryos.
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