Ferulic acid-induced anti-depression and prokinetics similar to Chaihu-Shugan-San via polypharmacology.
作者： Ying-jin Zhang , Xi Huang , Yang Wang , Ying Xie , Xin-jiang Qiu
DOI: 10.1016/J.BRAINRESBULL.2011.07.002
关键词:
摘要: Selective serotonin reuptake inhibitors (SSRIs), one of popular antidepressants as "one-compound-one-target" paradigm, cannot but discontinue because inhibiting gut movement. Traditional Chinese medicine (TCM) Chaihu-Sugan-San (CSS) can simultaneously exert anti-depression and prokinetics. From this thread, we aimed to find a new antidepressant with polypharmacological mechanisms. In vivo antidepressive prokinetic comparisons between CSS its absorbed compound ferulic acid (FA) were made. And FA's action mechanisms involved in monoaminergic systems, HPA axis gastrointestinal peptide ghrelin was then studied forced swimming test (FST) rat. Lastly, the jejunal contraction activity evoked by FA measured vitro. Compared vehicle, reduced immobility time, increased locomotor activity, accelerated gastric emptying intestinal transit similar whose absorbable component identified hippocampus jejunum. prokinetics further supported FA-induced anti-immobility prevented pretreated PCPA, WAY-100635, ketanserin, sulpiride, SCH233390, haloperidol yohimbine, respectively. CRH, ACTH 5-HT significantly decreased, apparently compared vehicle. summary, induced via serotonin, norepinephrine dopamine reuptakes, regulating axis, increasing stimulating simultaneously.
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