Laboratory diagnosis of malaria in nonhuman primates.

摘要: Abstract: Nonhuman primates (NHPs) are commonly used for biomedical research because of the high level gene homology that underlies physiologic similarity to human beings. Malaria parasites genus Plasmodium cause one most frequent parasitic diseases NHPs originating from tropical and subtropical areas as such represent a significant confounder. in presents diagnostic challenge especially those laboratories see no more than few malaria cases per year NHPs. The accurate timely diagnosis infection facilitates appropriate treatment individuals infected with parasites. Conventional microscopy based on examination Giemsa-stained thick thin blood films remains mainstay laboratory sensitivity specificity also capability species identification parasite counts. This procedure is recognized technically difficult time-consuming, requiring considerable training obtain necessary skills. In past years, efforts replace traditional but tedious reading have led different techniques detection parasites, including fluorescence microscopy, intraleukocytic hemozoin or pigment using automated cell analyzers, immunochromatographic rapid tests antigen detection, PCR assays. These offer new approaches diagnosing review focuses available tools