Transgenic oncogene mice. Tumor phenotype predicts genotype.

摘要: The hypothesis that oncogenes influence tumor phenotype was tested by examining slides from 607 mammary tumors 407 transgenic mice bearing the ras, myc, and/or neu oncogenes. Most (91%) had patterns (phenotypes) could not be classified Dunn's standard nomenclature. nonstandard were described as eosinophilic small cell (SC), basophilic large (LC), or pale intermediate (IC). SC associated with LC and IC neu, specificities more than .90 sensitivities ranging .99 to .48. Thus, used predict which oncogene present in animal. presence of myc combination either ras resulted predominance accelerated tumorigenesis. a decreased incidence. knowledge natural history disease.