Iron accumulates in the lavage and explanted lungs of cystic fibrosis patients

摘要: Oxidative stress participates in the pathophysiology of cystic fibrosis (CF). An underlying disruption iron homeostasis can frequently be demonstrated injuries and diseases associated with an oxidative stress. We tested hypothesis that accumulation altered expression iron-related proteins could both bronchoalveolar lavage (BAL) fluid explanted lungs patients fibrosis. BAL collected from 10 children CF showed elevated concentrations protein, iron, ferritin, transferrin, heme, hemoglobin relative to obtained 20 healthy volunteers. Using Perl's Prussian blue staining, lung revealed increased alveolar interstitial macrophages. Similarly, there was importer DMT1, exporter ferroportin 1 tissue patients. conclude is disrupted this metal being evident lungs.