Prophylactic L-arginine and ibuprofen delay the development of tactile allodynia and suppress spinal miR-155 in a rat model of diabetic neuropathy

摘要: Diabetic neuropathy (DN) is a common complication of diabetes mellitus that hardly reversible at the late stages. Since treatment neuropathic pain predominantly symptomatic, prophylactic measure would be useful. Both ibuprofen and L-arginine exert antiallodynic effects on chronic constriction injury (CCI)-induced cold allodynia. Furthermore, effective in CCI-induced mechanical The aim study was to assess effect streptozotocin-induced DN rats further investigate role spinal miR-155 nitric oxide (NO) this effect. Tactile allodynia assessed weekly by von Frey filaments. Oral daily administration ibuprofen, their combination, for 4 weeks starting 1 week after streptozotocin injection (ie, before development tactile allodynia), resulted significant decrease compared with control diabetic group. This evident fifth experiment. 3 treatments prevented muscle fiber diameter epidermal thickness, seen combination increase NO level miRNA-155, In conclusion, both delayed behavioral histologic changes DN, concomitant suppression level. being tolerable may useful prophylactically patients.