Long-term modification on histamine-induced bronchoconstriction by disodium cromoglycate and ketotifen versus placebo.
作者： F. Gozalo Reques , C. Colas Sanz , C. Senent Sanchez , M. Rubio Sotes , T. Herrero Lopez
DOI: 10.1111/J.1398-9995.1985.TB00228.X
关键词:
摘要: In order to compare long-term changes induced on a wide spectrum of bronchial hyperreactivity (BH) by the antiallergic drugs disodium cromoglycate (DSCG) and ketotifen, 56 asthmatic patients (age range 15-55 years) were studied. Patients allocated three groups with similar age BH level. During 2 months, 15 individuals inhaled 20 mg DSCG four times day, 14 took ketotifen 1 twice day orally one placebo (lactose) capsule day. After preliminary results, an additional group 13 clemastine for week. Only differed significantly from shifting log dose-response curves histamine. addition, no significant difference was seen between groups. These results suggest that mainly related its powerful antihistamine action; similarly, nonspecific is not wholly dependent mediator release.
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