Preventive effect of ketotifen, a new antiallergic agent, on histamine-induced bronchoconstriction in asthmatics.

摘要: The preventive effect of ketotifen, a new drug with anti-histaminic and antiallergic properties, on histamine-induced bronchoconstriction was studied by open assessment in twenty-four adult patients extrinsic asthma. A single oral dose 1 mg ketotifen reduced the post-histamine mean drop peak expiratory flow from 33 to 16% basal values (P less than 0.001). After 4 weeks' regimen twice daily post-drug fall PEF further significantly Tests performed after 8 12 weeks treatment showed no additional decrease bronchial reactivity histamine. week cessation return pretreatment level. results suggest that has marked this is enhanced during continued treatment.