Role of infectious agents in systemic rheumatic diseases

摘要: The relationship between infection and autoimmunity has been increasingly defined over the last twenty years or so. It is now quite clear that, in genetically susceptible individuals, environmental factors (mainly infections) play a critical role pathogenesis of autoimmune diseases. believed that infections contribute to maturation immune system from innate adoptive phases, bacterial viral are arthritogenic stimulants leading various rheumatic conditions. A failure isolate these microorganisms probably due action system, but often casts doubt on their Among bacteria, Helicobacter pylori associated with diseases such as gastritis, Sjogren's syndrome, atherosclerosis, thrombocytopenia purpura, inflammatory bowel pancreatitis, each which it seems pathogenatic, also suggested may help protect against development multiple sclerosis, systemic lupus erythemathosus Infectious agents dual etiopathogenesis antiphospholipid syndrome (APS): they be initial trigger production antibodies cross-reacting beta 2 glycoprotein I (Beta2GPI) infectious peptides, induce an response. According two-hit theory, pathogenetic anti-Beta2GPI act first hit whereas responses represent second slowly growing Propionibacterium acnes involved SAPHO non-specific activation cell-mediated immunity. Its ability persist bone lesions form incompatible culturing suggests possibility arthritis secondary "persistent" infection.