An expanding role for cell biologists in drug discovery and pharmacology

作者: Peter K. Sorger , Birgit Schoeberl

DOI: 10.1091/MBC.E12-05-0394

关键词:

摘要: The profound challenges facing clinicians, who must prescribe drugs in the face of dramatic variability response, and pharmaceutical industry, which develop new despite ever-rising costs, represent opportunities for cell biologists interested rethinking conceptual basis pharmacology drug discovery. Much better understanding is required quantitative behaviors networks targeted by cells, tissues, organisms. Cell these topics should learn more about basic structure development campaigns hone their programming skills. A world engaging industry-academic collaborations awaits, all with promise delivering real benefit to patients strained healthcare systems.

参考文章(13)
Patrick Chène, Can biochemistry drive drug discovery beyond simple potency measurements Drug Discovery Today. ,vol. 17, pp. 388- 395 ,(2012) , 10.1016/J.DRUDIS.2012.01.022
Gary J. Kelloff, Caroline C. Sigman, Cancer biomarkers: selecting the right drug for the right patient Nature Reviews Drug Discovery. ,vol. 11, pp. 201- 214 ,(2012) , 10.1038/NRD3651
Timothy J. Mitchison, The proliferation rate paradox in antimitotic chemotherapy Molecular Biology of the Cell. ,vol. 23, pp. 1- 6 ,(2012) , 10.1091/MBC.E10-04-0335
A J Atkinson, R L Lalonde, Introduction of quantitative methods in pharmacology and clinical pharmacology: a historical overview. Clinical Pharmacology & Therapeutics. ,vol. 82, pp. 3- 6 ,(2007) , 10.1038/SJ.CLPT.6100248
Dennis Huszar, Maria-Elena Theoclitou, Jeffrey Skolnik, Ronald Herbst, Kinesin motor proteins as targets for cancer therapy. Cancer and Metastasis Reviews. ,vol. 28, pp. 197- 208 ,(2009) , 10.1007/S10555-009-9185-8
Malorye Allison, NCATS launches drug repurposing program Nature Biotechnology. ,vol. 30, pp. 571- 572 ,(2012) , 10.1038/NBT0712-571A
T. N. Chonghaile, K. A. Sarosiek, T.-T. Vo, J. A. Ryan, A. Tammareddi, V. D. G. Moore, J. Deng, K. C. Anderson, P. Richardson, Y.-T. Tai, C. S. Mitsiades, U. A. Matulonis, R. Drapkin, R. Stone, D. J. DeAngelo, D. J. McConkey, S. E. Sallan, L. Silverman, M. S. Hirsch, D. R. Carrasco, A. Letai, Pretreatment Mitochondrial Priming Correlates with Clinical Response to Cytotoxic Chemotherapy Science. ,vol. 334, pp. 1129- 1133 ,(2011) , 10.1126/SCIENCE.1206727
S. I. Berger, R. Iyengar, Network analyses in systems pharmacology Bioinformatics. ,vol. 25, pp. 2466- 2472 ,(2009) , 10.1093/BIOINFORMATICS/BTP465
Joseph Loscalzo, Albert-Laszlo Barabasi, Systems Biology and the Future of Medicine Wiley Interdisciplinary Reviews: Systems Biology and Medicine. ,vol. 3, pp. 619- 627 ,(2011) , 10.1002/WSBM.144
Steven M. Paul, Daniel S. Mytelka, Christopher T. Dunwiddie, Charles C. Persinger, Bernard H. Munos, Stacy R. Lindborg, Aaron L. Schacht, How to improve R&D productivity: the pharmaceutical industry's grand challenge Nature Reviews Drug Discovery. ,vol. 9, pp. 203- 214 ,(2010) , 10.1038/NRD3078