Elevated Baseline C-Reactive Protein as a Predictor of Outcome After Aneurysmal Subarachnoid Hemorrhage: Data From the Simvastatin in Aneurysmal Subarachnoid Hemorrhage (STASH) Trial.

摘要: There remains a proportion of patients with unfavorable outcomes after aneurysmal subarachnoid hemorrhage, particular relevance in those who present good clinical grade. A forewarning at risk provides an opportunity towards more intensive monitoring, investigation, and prophylactic treatment prior to the manifestation advancing cerebral injury. OBJECTIVE: To assess whether biochemical markers sampled first days initial hemorrhage can predict poor outcome. METHODS: All recruited multicenter Simvastatin Aneurysmal Hemorrhage Trial (STASH) were included. Baseline profiles taken between time ictus day 4 post ictus. The t-test compared outcomes, backwards stepwise binary logistic regression was used determine factors providing independent prediction outcome. RESULTS: Baseline data obtained approximately 91% cases from 803 patients. On admission, 73% grade (World Federation Neurological Surgeons grades 1 or 2); however, 84% had Fisher 3 on computed tomographic scan. For presenting higher levels C-reactive protein, glucose, white blood cells lower hematocrit, albumin, hemoglobin associated outcome discharge. protein found be predictor for grade. CONCLUSION: Early recording may prove useful detecting are greater deterioration outcome. ABBREVIATIONS: ALP, alkaline phosphatase ALT, alanine aminotransferase CK, creatine kinase CRP, protein EVD, external ventricular drainage ICH GCP, International Conference Harmonisation guidelines practice mRS, modified Rankin Scale SAH, hemorrhage STASH, Subarachnoid Trial WBC, cells WFNS, World