In-hospital C-reactive protein predicts outcome after aneurysmal subarachnoid haemorrhage treated by endovascular coiling.

摘要: Background This study aimed to examine prospectively whether the inflammatory marker C-reactive protein (CRP) increases in patients with aneurysmal subarachnoid haemorrhage (aSAH) treated by endovascular coiling and investigate CRP could be used as prognostic factor for long-term neurological outcome. Methods This single-hospital comprised 98 consecutive confirmed aSAH coiling. Admission status was classified according World Federation of Neurosurgical Societies (WFNS) Scale initial cerebral computed tomography Fisher scale. analysed on days 0, 1, 2, 3, 4, 6 8 after bleed. A follow up performed 1 year later Extended Glasgow Outcome (GOSE) overall outcome National Institute Health Stroke (NIHSS) focal deficit. Results CRP values increased from normal peak at 53 mg/l day 3–4 then declined, without normalising, 8. Patients a higher increase had poorer year. during first week stronger correlation (r = 0.417) NIHSS (r = 0.449) than clinical (WFNS; r = 0.280 0.274) radiology (Fisher scale; r = 0.137 0.158). indicated risk poor (P < 0.001) permanent loss function (P < 0.001). Logistic regression analysis suggested that elevated already 2 is an independent outcome. Conclusion Early can perhaps prediction treatment aSAH.