The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3

作者: Rüdiger Klein , Venkata Nanduri , Shuqian Jing , Fabienne Lamballe , Peter Tapley

DOI: 10.1016/0092-8674(91)90628-C

关键词:

摘要: trkB is a tyrosine protein kinase gene highly related to trk, proto-oncogene that encodes receptor for nerve growth factor (NGF) and neurotrophin-3 (NT-3). expression confined structures of the central peripheral nervous systems, suggesting it also neurotrophic factors. Here we show brain-derived (BDNF) NT-3, but not NGF, can induce rapid phosphorylation on gp145trkB, one receptors encoded by trkB. BDNF NT-3 DNA synthesis in quiescent NIH 3T3 cells express gp145trkB. Cotransfection plasmids encoding gp145trkB or leads transformation recipient cells. In these assays, elicits response at least two orders magnitude higher than NT-3. Finally, 125I-NT-3 binds expressing gp145trkB; binding be competed NGF. These findings indicate may function as

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