Further Characterization of Quinpirole-Elicited Yawning as a Model of Dopamine D3 Receptor Activation in Male and Female Monkeys

摘要: The dopamine (DA) D3 receptor (D3R) has been associated with impulsivity, pathologic gambling, and drug addiction, making it a potential target for pharmacotherapy development. Positron emission tomography studies using the D3R-preferring radioligand [11C]PHNO ([11C](+)-propyl-hexahydro-naphtho-oxazin) have shown higher binding potentials in abusers compared control subjects. Preclinical examined D3R activation DA agonist quinpirole unconditioned behavior of yawning. However, relationship between quinpirole-elicited yawning availability not determined. In Experiment 1, eight drug-naive male rhesus monkeys were scanned [11C]PHNO, ability (0.01–0.3 mg/kg i.m.) to elicit was examined. Significant positive (globus pallidus) negative (caudate nucleus, putamen, ventral pallidum, hippocampus) relationships quinpirole-induced yawns noted. 2 replicated earlier findings that history cocaine self-administration (n = 11) did affect extended this examine 3) methamphetamine (MA) found experience self-administering MA showed greater potency significantly controls. Finally, studied female 6) 8). Sex differences noted, being more potent eliciting males females. Taken together these support use as behavioral tool examining both sex may influence individual sensitivity effects compounds.