Effect of high-potency cannabis on corpus callosum microstructure.

摘要: BACKGROUND: The use of cannabis with higher Δ9-tetrahydrocannabinol content has been associated greater risk, and earlier onset, psychosis. However, the effect potency on brain morphology never explored. Here, we investigated whether pattern are changes in corpus callosum (CC) microstructural organization, patients first-episode psychosis (FEP) individuals without psychosis, users non-users. METHOD: CC 56 FEP (37 users) 43 (22 was virtually dissected segmented using diffusion tensor imaging tractography. index fractional anisotropy, mean diffusivity (MD), axial (AD) radial calculated for each segment. RESULTS: Across whole sample, high-potency had total MD AD than both low-potency those who used (p = 0.005 p 0.004, respectively). Daily also occasional 0.001 < 0.001, there no group (patient/individuals psychosis) or x interaction either frequency use. within-group analysis showed fact that effects were similar CONCLUSIONS: Frequent is disturbed callosal organization Since preparations now replacing traditional herbal drugs many European countries, raising awareness about risks crucial.