Discriminative Properties of Hippocampal Hypoperfusion in Marijuana Users Compared to Healthy Controls: Implications for Marijuana Administration in Alzheimer's Dementia

摘要: BACKGROUND Few studies have evaluated the impact of marijuana use on regional cerebral blood flow. OBJECTIVE To determine whether perfusion in specific brain regions functional neuroimaging, including those affected by Alzheimer's disease pathology, are abnormal users compared to controls. METHOD Persons with a diagnosis cannabis disorder DSM-IV and DSM-V criteria (n = 982) were controls (n = 92) neuroimaging SPECT at rest concentration task. Perfusion estimates quantified using standard atlas. Cerebral differences calculated one-way ANOVA. Diagnostic separation was determined discriminant analysis all subjects. Feature selection minimum redundancy maximum relevancy (mRMR) identified predictive subset (n = 436) reduced psychiatric co-morbidities. RESULTS Marijuana showed lower average (p < 0.05). Discriminant distinguished from correct classification 96% leave one out cross-validation 92%. With regions, there 95% leave-one-out cross validation 90%. AUC for accuracy, 90% sensitivity, 83% specificity. The mRMR right hippocampal hypoperfusion imaging most separating subjects CONCLUSION Multiple show low users. region distinguishing healthy controls, hippocampus, is key target pathology. This study raises possibility deleterious effects use.