Somatic Mutation Spectrum of Non-Small-Cell Lung Cancer in African Americans: A Pooled Analysis.

摘要: Introduction: The mutational profile of non–small-cell lung cancer (NSCLC) has become an important tool in tailoring therapy to patients, with clear differences according the population origin. African Americans (AAs) have higher incidence and mortality than Caucasians, yet discrepant results been reported regarding frequency somatic driver mutations. We hypothesized that NSCLC a distinct this group. Methods: collected samples resected from self-reported AAs five sites Tennessee, Michigan, Ohio. Gene mutations were assessed by either SNaPshot or next generation sequencing, ALK translocations evaluated fluorescence situ hybridization. Results: Two hundred sixty patients included, mostly males (62.3%) smokers (86.6%). Eighty-one (31.2%) squamous cell carcinomas. most frequently mutated genes KRAS (15.4%), epidermal growth factor receptor ( EGFR, 5.0%), PIK3CA (0.8%), BRAF, NRAS, ERBB2, AKT1 (0.4% each). detected two nonsquamous tumors (1.7%), totaling 61 cases (23.5%) oncogenic alterations. Among 179 samples, 54 (30.2%) presented alteration. alterations altogether was lower whereas no difference EGFR Overall survival longer among Conclusions: demonstrated different pattern Caucasians. majority group are be described, which will require more comprehensive panels assessment noncanonical