Frequency of EGFR and KRAS Mutations in Lung Adenocarcinomas in African Americans

摘要: Introduction: The detection of mutations in the epidermal growth factor receptor ( EGFR ) gene, which predict sensitivity to treatment with tyrosine kinase inhibitors, represents a major advance lung adenocarcinoma. KRAS confer resistance -tyrosine inhibitors. prevalence these African American patients has not been thoroughly investigated. Methods: We collected formalin-fixed, paraffin-embedded material from resected adenocarcinomas at three institutions for DNA extraction. frequencies exon 19 deletions, 21 L858R substitutions, and tumor specimens were compared data white n = 476). Results: detected 23 121 (19%, 95% confidence interval [CI]: 13–27%), whereas found (17%, CI: 12–25%). There was no significant difference between comparing patients, 19% versus 13% (61/476, 10–16%; p 0.11). more likely among whites, 26% (125/476, 23–30%; 0.04). Conclusions: This is largest study date examining frequency Americans. Although somewhat less likely, there when whites. These results suggest that all advanced should undergo mutational analysis before initiation therapy.