EGFR Mutations in Lung Adenocarcinomas: Clinical Testing Experience and Relationship to EGFR Gene Copy Number and Immunohistochemical Expression

作者: Allan R. Li , Dhananjay Chitale , Gregory J. Riely , William Pao , Vincent A. Miller

DOI: 10.2353/JMOLDX.2008.070178

关键词:

摘要: … In conclusion, lung adenocarcinoma with EGFR mutations is a distinct biological subset as … high response rate to EGFR TKIs. Amplification of EGFR in NSCLC with EGFR mutation is …

参考文章(25)
U Pastorino, S Andreola, E Tagliabue, F Pezzella, M Incarbone, G Sozzi, M Buyse, S Menard, M Pierotti, F Rilke, Immunocytochemical markers in stage I lung cancer: relevance to prognosis. Journal of Clinical Oncology. ,vol. 15, pp. 2858- 2865 ,(1997) , 10.1200/JCO.1997.15.8.2858
William Pao, Marc Ladanyi, Epidermal growth factor receptor mutation testing in lung cancer: searching for the ideal method. Clinical Cancer Research. ,vol. 13, pp. 4954- 4955 ,(2007) , 10.1158/1078-0432.CCR-07-1387
Qiulu Pan, William Pao, Marc Ladanyi, Rapid Polymerase Chain Reaction-Based Detection of Epidermal Growth Factor Receptor Gene Mutations in Lung Adenocarcinomas The Journal of Molecular Diagnostics. ,vol. 7, pp. 396- 403 ,(2005) , 10.1016/S1525-1578(10)60569-7
Rohit Bhargava, William L Gerald, Allan R Li, Qiulu Pan, Priti Lal, Marc Ladanyi, Beiyun Chen, EGFR gene amplification in breast cancer: correlation with epidermal growth factor receptor mRNA and protein expression and HER-2 status and absence of EGFR -activating mutations Modern Pathology. ,vol. 18, pp. 1027- 1033 ,(2005) , 10.1038/MODPATHOL.3800438
Federico Cappuzzo, Fred R. Hirsch, Elisa Rossi, Stefania Bartolini, Giovanni L. Ceresoli, Lynne Bemis, Jerry Haney, Samir Witta, Kathleen Danenberg, Irene Domenichini, Vienna Ludovini, Elisabetta Magrini, Vanesa Gregorc, Claudio Doglioni, Angelo Sidoni, Maurizio Tonato, Wilbur A. Franklin, Lucio Crino, Paul A. Bunn, Marileila Varella-Garcia, Epidermal Growth Factor Receptor Gene and Protein and Gefitinib Sensitivity in Non–Small-Cell Lung Cancer Journal of the National Cancer Institute. ,vol. 97, pp. 643- 655 ,(2005) , 10.1093/JNCI/DJI112
Lynette M Sholl, A John Iafrate, Yi-Ping Chou, Ming-Tsang Wu, Yih-Gang Goan, Li Su, Yen-Tsung Huang, David C Christiani, Lucian R Chirieac, Validation of chromogenic in situ hybridization for detection of EGFR copy number amplification in nonsmall cell lung carcinoma. Modern Pathology. ,vol. 20, pp. 1028- 1035 ,(2007) , 10.1038/MODPATHOL.3800946
Marc Ladanyi, William Pao, Lung adenocarcinoma: guiding EGFR-targeted therapy and beyond. Modern Pathology. ,vol. 21, ,(2008) , 10.1038/MODPATHOL.3801018
Lecia V. Sequist, Daphne W. Bell, Thomas J. Lynch, Daniel A. Haber, Molecular Predictors of Response to Epidermal Growth Factor Receptor Antagonists in Non–Small-Cell Lung Cancer Journal of Clinical Oncology. ,vol. 25, pp. 587- 595 ,(2007) , 10.1200/JCO.2006.07.3585
Toshihiko Yokoyama, Masashi Kondo, Yasuhiro Goto, Takayuki Fukui, Hiromu Yoshioka, Kohei Yokoi, Hirotaka Osada, Kazuyoshi Imaizumi, Yoshinori Hasegawa, Kaoru Shimokata, Yoshitaka Sekido, EGFR point mutation in non-small cell lung cancer is occasionally accompanied by a second mutation or amplification. Cancer Science. ,vol. 97, pp. 753- 759 ,(2006) , 10.1111/J.1349-7006.2006.00233.X
Thomas J. Lynch, Daphne W. Bell, Raffaella Sordella, Sarada Gurubhagavatula, Ross A. Okimoto, Brian W. Brannigan, Patricia L. Harris, Sara M. Haserlat, Jeffrey G. Supko, Frank G. Haluska, David N. Louis, David C. Christiani, Jeff Settleman, Daniel A. Haber, Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib The New England Journal of Medicine. ,vol. 350, pp. 2129- 2139 ,(2004) , 10.1056/NEJMOA040938