Mutations in the tyrosine kinase domain of the epidermal growth factor receptor in non-small cell lung cancer.

摘要: We evaluated somatic genetic alterations in the kinase domain of EGFR gene tumors 219 non-small cell lung cancer patients primarily Caucasian and African American origins. identified 26 (12%) whose had a mutation gene, 11 (5%) carried novel genomic variations consistent with germ-line polymorphisms. All but one were affected adenocarcinoma. mutations more frequent women nonsmokers, significant portion men (12 26) current or past smokers accounted for half (13 26). Screening subjects may identify could respond to targeted therapy using tyrosine inhibitors.