Trans-ethnic genome-wide meta-analysis of 35,732 cases and 34,424 controls identifies novel genomic cross-ancestry loci contributing to lung cancer susceptibility
作者： Jinyoung Byun , Younghun Han , Yafang Li , Jun Xia , Xiangjun Xiao
DOI: 10.1101/2020.10.06.20207753
关键词:
摘要: Lung cancer is the leading cause of death worldwide. Genome-wide association studies have revealed genetic risk factors, highlighting role smoking, family history, telomere regulation, and DNA damage-repair in lung etiology. Many focused on a single ethnic group to avoid confounding from variability allele frequencies across populations; however, comprehensive multi-ethnic analyses may identify variants that are more likely be causal. This large-scale, meta-analyses identified 28 novel loci achieving genome-wide significance. Leading candidates were further studied using single-cell methods for evaluating DNA-damage. DNA-damage promoting activities confirmed selected genes by knockdown overexpression studies.
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