Anti-Inflammatory Properties of Flavone di-C-Glycosides as Active Principles of Camellia Mistletoe, Korthalsella japonica.
作者： Min Kyoung Kim , Kwang Jun Yun , Da Hae Lim , Jinju Kim , Young Pyo Jang
DOI: 10.4062/BIOMOLTHER.2016.019
关键词:
摘要: The chemical components and biological activity of Camellia mistletoe, Korthalsella japonica (Loranthaceae) are relatively unknown compared to other mistletoe species. Therefore, we investigated the phytochemical properties this parasitic plant provide essential preliminary scientific evidence support encourage its further pharmaceutical research development. major were chromatographically isolated using high-performance liquid chromatography their structures elucidated tandem mass spectrometry nuclear magnetic resonance anlysis. Furthermore, anti-inflammatory 70% ethanol extract K. (KJ) was evaluated a nitric oxide (NO) assay western blot analysis for inducible NO synthase (iNOS) cyclooxygenase (COX)-2. Three flavone di-C-glycosides, lucenin-2, vicenin-2, stellarin-2 identified as KJ, first time. KJ significantly inhibited production reduced iNOS COX-2 expression in lipopolysaccharide-stimulated RAW 264.7 cells at 100 µg/ mL while similar observed with C-glycosides. In conclusion, has simple secondary metabolite profiles including di-C-glycosides strong potential development source therapeutic agents.
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