CBX3/heterochromatin protein 1 gamma is significantly upregulated in patients with non–small cell lung cancer

摘要: Aim Lung cancer is typically categorized into small cell lung (SCLC) and non–small (NSCLC). NSCLC comprises of the majority with a poor prognosis in advanced cases. Transcriptional profiling studies, including microarrays RNA-sequencing have significantly enriched our knowledge gene expression patterns NSCLC. A recent transcriptional study identified high prevalence CBX3/HP1-gamma upregulation human samples. an isoform heterochromatin protein 1 family, which plays role formation linked to cancer. Methods We examined samples from hospital using immunohistochemistry for staining. We also analyzed publicly available databases validate results. Results We (77.2%) positive staining by patient Independently, we queried dataset (GSE40419) containing RNA-seq data 77 patients. Upregulation tumor was present 60.2% similar correlation observed The Cancer Genome Atlas (TCGA) database. Interestingly, discovered highly significant association between EGFR mutation (40 42 patients, P < 0.001). Treatment mutant lines inhibitor gefitinib failed yield change CBX/HP1-gamma expression, suggesting that may be independent downstream signaling. Conclusion We report possible relationship mutation.