Simultaneous exposure to multiple heavy metals and glyphosate may contribute to Sri Lankan agricultural nephropathy

摘要: Sri Lankan Agricultural Nephropathy (SAN), a new form of chronic kidney disease among paddy farmers was first reported in 1994. It has now become the most debilitating public health issue dry zone Lanka. Previous studies showed SAN is tubulo-interstitial type nephropathy and exposure to arsenic cadmium may play role pathogenesis disease. Urine samples patients with (N = 10) from Padavi-Sripura, endemic area, two sets controls, one healthy participants same area other non-endemic (N = 10; Colombo district) were analyzed for 19 heavy metals presence pesticide- glyphosate. In both cases controls who live region, median concentrations urinary Sb, As, Cd, Co, Pb, Mn, Ni, Ti V exceed reference range. With exception Mo Al, Cu, Mo, Se, Zn creatinine adjusted values glyphosate significantly higher when compared controls. Creatinine unadjusted significant 14 20 chemicals studied 7 patients, The highest concentration recorded (range 61.0-195.1 μg/g creatinine). People exposed multiple Results are supportive toxicological origin that confined specific geographical areas. Although we could not localize single nephrotoxin as culprit SAN, glyphosates pathogenesis. Heavy excessively present urine capable causing damage kidneys. Synergistic effects agrochemicals be nephrotoxic.