Sequence Variants and the Risk of Head and Neck Cancer: Pooled Analysis in the INHANCE Consortium

摘要: Previous molecular epidemiological studies on head and neck cancer have examined various single nucleotide polymorphisms, but there are very few documented associations. In the International Head Neck Cancer Epidemiology (INHANCE) consortium, we evaluated associations between SNPs in metabolism, cell cycle, DNA repair pathways risk of cancer. We analyzed individual-level pooled data from 14 European, North American, Central American Asia case-control (5,915 cases 10,644 controls) participating INHANCE consortium. Unconditional logistic regression was used to estimate odds ratios (OR) 95% confidence intervals (CI) for SNP effects, adjusting age, sex, race, country. observed an association MGMT Leu84Phe heterozygotes (OR=0.79, CI=0.68-0.93), XRCC1 Arg194Trp rare homozygotes (OR=2.3, CI=1.1-4.7), ADH1B Arg48His Arg/Arg (OR=2.7, CI=1.9-4.0), ADH1C Ile350Val Ile/Ile (OR=1.2, CI=1.1-1.4), GSTM1 null genotype (OR=1.1, CI=1.0-1.2). Among these results, Leu84Phe, Arg48His, Ile350Arg, had fairly low false positive report probabilities (<20%). risk. No functional study currently supports with may be a chance finding.