One-carbon metabolism-related gene polymorphisms and risk of head and neck squamous cell carcinoma: Case-control study
作者： Takeshi Suzuki , Keitaro Matsuo , Yasuhisa Hasegawa , Akio Hiraki , Kenji Wakai
DOI: 10.1111/J.1349-7006.2007.00533.X
关键词:
摘要: Low consumption of vegetables and fruits, which leads to insufficient folate intake, is associated with increased risk several types cancer, including head neck squamous cell carcinoma (HNSCC). Functional polymorphisms in genes encoding one-carbon metabolism enzymes, such as methylenetetrahydrofolate reductase (MTHFR C677T A1298C), methionine synthase (MTR A2756G), (MTRR A66G) thymidylate (TS), influence thus might impact on HNSCC risk. We conducted a case-control study 237 cases newly histologically diagnosed 711 age- sex-matched non-cancer controls clarify associations these five polymorphisms. Gene-environment interactions between smoking drinking habit were also evaluated by logistic regression analysis. Dietary intake was inversely None the showed any significant genotype alone, but we found MTHFR C667T (P = 0.04), MTR A2756G 0.04) MTRR A66G 0.03) The results suggest that there may be metabolism-related alcohol for
sci-hub.se 参考文章(44)
Shinkan Tokudome, Chiho Goto, Nahomi Imaeda, Yuko Tokudome, Masato Ikeda, Shinzo Maki, Development of a data-based short food frequency questionnaire for assessing nutrient intake by middle-aged Japanese. Asian Pacific Journal of Cancer Prevention. ,vol. 5, pp. 40- 43 ,(2004)
R Talamini, S Vaccarella, F Barbone, A Tavani, C La Vecchia, R Herrero, N Muñoz, S Franceschi, Oral hygiene, dentition, sexual habits and risk of oral cancer. British Journal of Cancer. ,vol. 83, pp. 1238- 1242 ,(2000) , 10.1054/BJOC.2000.1398
S. Tokudome, M. Ikeda, Y. Tokudome, N. Imaeda, I. Kitagawa, N. Fujiwara, Development of Data-based Semi-quantitative Food Frequency Questionnaire for Dietary Studies in Middle-aged Japanese Japanese Journal of Clinical Oncology. ,vol. 28, pp. 679- 687 ,(1998) , 10.1093/JJCO/28.11.679
Ilan Weisberg, Pamela Tran, Benedicte Christensen, Sahar Sibani, Rima Rozen, A Second Genetic Polymorphism in Methylenetetrahydrofolate Reductase (MTHFR) Associated with Decreased Enzyme Activity Molecular Genetics and Metabolism. ,vol. 64, pp. 169- 172 ,(1998) , 10.1006/MGME.1998.2714
Kristi A. Steinmetz, John D. Potter, Vegetables, fruit, and cancer. II. Mechanisms. Cancer Causes & Control. ,vol. 2, pp. 427- 442 ,(1991) , 10.1007/BF00054304
Eva Negri, Silvia Franceschi, Cristina Bosetti, Fabio Levi, Ettore Conti, Maria Parpinel, Carlo La Vecchia, Selected micronutrients and oral and pharyngeal cancer. International Journal of Cancer. ,vol. 86, pp. 122- 127 ,(2000) , 10.1002/(SICI)1097-0215(20000401)86:1<122::AID-IJC19>3.0.CO;2-2
S. Goelz, B Vogelstein, Hamilton, A. Feinberg, Hypomethylation of DNA from benign and malignant human colon neoplasms. Science. ,vol. 228, pp. 187- 190 ,(1985) , 10.1126/SCIENCE.2579435
John D Potter, Vegetables, fruit, and cancer. The Lancet. ,vol. 366, pp. 527- 530 ,(2005) , 10.1016/S0140-6736(05)67077-8
Aaron Wilson, Robert Platt, Qing Wu, Daniel Leclerc, Benedicte Christensen, Hong Yang, Roy A. Gravel, Rima Rozen, A Common Variant in Methionine Synthase Reductase Combined with Low Cobalamin (Vitamin B12) Increases Risk for Spina Bifida Molecular Genetics and Metabolism. ,vol. 67, pp. 317- 323 ,(1999) , 10.1006/MGME.1999.2879
Tomoko Imai, Mieko Nakamura, Fujiko Ando, Hiroshi Shimokata, Dietary Supplement Use by Community-living Population in Japan: Data from the National Institute for Longevity Sciences Longitudinal Study of Aging (NILS-LSA) Journal of Epidemiology. ,vol. 16, pp. 249- 260 ,(2006) , 10.2188/JEA.16.249