Tumor suppressor genes and medulloblastoma.

摘要: Although primary intracranial neoplasms are the most common type of solid cancer in children, little is known about their etiology at molecular genetic level. Recently, studies have shown that a class genes as tumor suppressors play an important role origin several different types human tumors, including those located central nervous system (CNS). Using variety techniques, selective loss DNA sequences has been identified tissue specimens from children with medulloblastoma, one pediatric brain tumors. The consistent losses to date for probes on distal chromosome arm 17p. suppressor p53 this chromosome, and deletion mutation gene events cancers many types, such alterations infrequently detected medulloblastoma specimens. These results suggest inactivation another or 17p tumorigenesis. Deletion also implications clinical management, strongly associated negative prognosis these patients. identification cloning will aid understanding pathogenesis well guiding development novel more effective strategies cure.