Some effects of the essential fatty acids linoleic acid and alpha-linolenic acid and of their metabolites gamma-linolenic acid, arachidonic acid, eicosapentaenoic acid, docosahexaenoic acid, and of prostaglandins A1 and E1 on the proliferation of human osteogenic sarcoma cells in culture.

摘要: Abstract Gamma-linolenic acid has been shown to suppress the rate of proliferation a number malignant cell lines in culture. To test proposal that this was specific prostaglandin l- or 2-series effect, 379 batches MG63 human osteogenic sarcoma cells were seeded Greiner flasks and cultured media supplemented with range unsaturated fatty acids prostaglandins. The monounsaturated oleic enhanced cancer proliferation. polyunsaturated linoleic acid, gamma-linolenic arachidonic alpha-linolenic eicosapentaenoic docosahexaenoic as well prostaglandins E1 A1 suppressed Total suppression colony forming occured at high levels supplementation. In addition form evening primrose seed oil vitamin C given 6 patients histologically diagnosed primary liver cancer. Some clinical improvement reduction tumor size 3 cases. One patient remarkable on CAT scan serum alkaline phosphatase from 2830 295 units γ-glutamyl transaminase 274 82 units. Thus preliminary results suggest may be effective management further trials should conducted. However, culture although essential proliferation, eicosanoids all series involved. suppressive effect suggests other aspects than only eicosanoid activity also important